= glossary definition
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Marfan Study Basics
The Marfan Trial studies Beta Blocker Therapy (Atenolol) versus Angiotensin II Receptor Blocker Therapy (Losartan) in Individuals with Marfan Syndrome. Marfan Syndrome (MFS) is a disorder that can affect the heart and large blood vessels as well as eyes, muscles, bones and lungs. The most serious problems can happen when the body's largest blood vessel, the , becomes enlarged in individuals with MFS. This study is being done to compare two drugs (Atenolol and Losartan) to see if one is better than the other at slowing the speed of aortic enlargement. The study will also compare the kinds of that can occur when taking either of these medicines. The study will enroll 604 individuals, aged 6 months to 25 years of age. The study began in February 2007 and will take about 7 years to finish.
You or your child can be in the study if:
If you or your child meets the requirements, the study will be explained to you in detail by one of the . Once your questions have been answered, you will be asked to sign an to enter the study. Some of the things that will happen during the study may be done only for study purposes. We will try very hard to time the tests required for the study with routine visits. We will also collect information on blood work and procedures that you or your child gets as part of routine clinical care.
This is what needs to be done in the study:
will be in contact with you frequently during the time your
child is in the study. You are free to call the nurse or study
coordinator at any time with any questions or concerns that
you may have.
You or your child will take the study drug for 3 years. We will continue to review your medical record for up to 5 years and we may contact you during that time to get more data on how you have been doing.
Although you or your child may not directly benefit from being in this study, your participation will allow your doctors to better understand which type of drug may be better for people with MFS.
Possible risks of being in this study come mainly from the type of drug you or your child may take. Each drug is usually tolerated well but can have side effects. We will closely monitor for side effects throughout the study and will discuss with you what can be done to help or prevent them.
There will be no additional costs for being in this study. Tests required by the study and that are not a part of regular care will be provided free of charge. You are responsible for all other costs related to your/your child's medical care such as hospitalization, surgery, drugs, lab tests and physicians fees which are considered standard medical care.