PHN Publications

Enalapril in Infants with Single Ventricle: results of a multicenter randomized trial (PDF), Hsu DT, Circulation 2010; 122:333-340.

Birth Weight and Prematurity in Infants With Single Ventricle Physiology: Pediatric Heart Network Infant Single Ventricle Trial Screened Population (PDF), R. Williams, Congenit Heart Dis 2010; 5:96-103.

Many congenital heart defects are associated with low birth weight and prematurity, but there is little information on birth characteristics of babies with a specific kind of defect, single ventricle physiology . This study compares birth parameters for babies enrolled in the Infant Single Ventricle Trial as compared to the typical US population. Infants with single ventricle had increased rates of preterm birth and low birth weight, and they were more likely to be small for gestational age than the general population.

Need main results paper when out.

Rationale and Design of a Trial of Angiotensin-Converting Enzyme Inhibition in Infants With Single Ventricle (PDF), D. Hsu, Am Heart J 2009; 157:37-45.

Angiotensin-converting enzyme (ACE) inhibitors are medicines  that improve heart function in adults with heart failure. Infants with a particular type of congenital heart defect (known as single ventricle ) have been shown to have abnormal heart function and poor growth. This study was designed to determine if giving ACE inhibitors to babies with single-ventricles would improve their growth, heart function and development. This article describes the design, the participants and the procedures of this trial.