Variable Label (VAR)	Variable Name	Category	N(%)	N(Missing)	Mean(SD)	Median(Q1,Q3)	Range of Values	
A1. Blind_ID	BLIND_ID			230(0)	473.29(273.28)	462.00(222.00,712.00)	2.00-919.00	
								
A2. Study visit	VISIT	Genetics visit	230(100.0)					
								
A4. Person providing the history	PERSON	Both parents	6(2.6)					
								
		Father	3(1.3)					
								
		Mother	220(95.7)					
								
		Other	1(0.4)					
								
B1. What is your (the mother's) age (years) at interview?	MOTHER_AGE_YEARS			229(1)	34.20(6.31)	33.97(29.66,39.48)	20.51-49.10	
								
B2. What is the father's (your) age (years) at interview?	FATHER_AGE_YEARS			216(14)	37.07(7.35)	36.29(31.68,41.61)	21.74-63.04	
								
B3. Are you (the mother) and the father (you) blood-related to each other? (History of consanguinity)	PARENT_RELAT	Don't know	1(0.4)					
								
		Missing	1(0.4)					
								
		No	224(97.4)					
								
		Yes	4(1.7)					
								
Source code	PARENT_SC	Both	6(2.6)					
								
		Med Record	2(0.9)					
								
		Missing	2(0.9)					
								
		Parent	220(95.7)					
								
B4. Did you (the mother) have an amniocentesis during this pregnancy?	AMNIOCENT	Don't know	1(0.4)					
								
		Missing	1(0.4)					
								
		No	143(62.2)					
								
		Yes	85(37.0)					
								
Source code	AMNIOCENT_SC	Both	8(3.5)					
								
		Med Record	2(0.9)					
								
		Missing	2(0.9)					
								
		Parent	218(94.8)					
								
a. Were the results normal?	AMN_RESULT	Don't know	2(0.9)					
								
		Missing	1(0.4)					
								
		No	3(1.3)					
								
		Skipped	144(62.6)					
								
		Yes	80(34.8)					
								
Source code	AMNIO_RES_SC	Both	1(0.4)					
								
		Med Record	1(0.4)					
								
		Missing	2(0.9)					
								
		Parent	82(35.7)					
								
		Skipped	144(62.6)					
								
b. IF NO: Please tell me what the results were. SPECIFY	AMN_ABNORM			()	()	(,)	-	
								
B5. Did you (the mother) have serum screening done?	SERUM	Don't know	30(13.0)					
								
		Missing	2(0.9)					
								
		No	102(44.3)					
								
		Yes	96(41.7)					
								
Source code	SERUM_SC	Both	9(3.9)					
								
		Med Record	1(0.4)					
								
		Missing	3(1.3)					
								
		Parent	217(94.3)					
								
a. Were the results normal?	SERUM_RESULT	Missing	2(0.9)					
								
		No	3(1.3)					
								
		Skipped	132(57.4)					
								
		Yes	93(40.4)					
								
Source code	SERUM_RES_SC	Both	1(0.4)					
								
		Missing	3(1.3)					
								
		Parent	94(40.9)					
								
		Skipped	132(57.4)					
								
b. IF NO: Please tell me what the results were. SPECIFY	SERUM_ABNORM			()	()	(,)	-	
								
B6. Did you (the mother) have a fetal ultrasound performed during this pregnancy?	ULTRASOUND	Missing	1(0.4)					
								
		No	8(3.5)					
								
		Yes	221(96.1)					
								
Source code	ULTRASOUN_SC	Both	12(5.2)					
								
		Med Record	2(0.9)					
								
		Missing	2(0.9)					
								
		Parent	214(93.0)					
								
a. Were the results normal?	ULTRA_RESULT	Don't know	1(0.4)					
								
		Missing	1(0.4)					
								
		No	172(74.8)					
								
		Skipped	8(3.5)					
								
		Yes	48(20.9)					
								
Source code	ULTRA_RES_SC	Both	12(5.2)					
								
		Med Record	5(2.2)					
								
		Missing	2(0.9)					
								
		Parent	203(88.3)					
								
		Skipped	8(3.5)					
								
b. IF NO: Please tell me what the results were. SPECIFY	ULTRA_ABNORM			()	()	(,)	-	
								
a. Cigarette smoking (primary or second hand smoke)	EXPOS_CIGAR	No	165(71.7)					
								
		Yes	65(28.3)					
								
Source code	EXP_CIGAR_SC	Both	4(1.7)					
								
		Med Record	2(0.9)					
								
		Missing	1(0.4)					
								
		Parent	223(97.0)					
								
b.  Alcohol	EXPOS_ALCOH	No	209(90.9)					
								
		Yes	21(9.1)					
								
Source code	EXP_ALCOH_SC	Both	5(2.2)					
								
		Med Record	2(0.9)					
								
		Missing	1(0.4)					
								
		Parent	222(96.5)					
								
c. Cocaine	EXPOS_COCAIN	Missing	1(0.4)					
								
		No	229(99.6)					
								
Source code	EXP_COCA_SC	Both	5(2.2)					
								
		Med Record	2(0.9)					
								
		Missing	2(0.9)					
								
		Parent	221(96.1)					
								
d. Heroin	EXPOS_HEROIN	Missing	1(0.4)					
								
		No	229(99.6)					
								
Source code	EXP_HEROI_SC	Both	5(2.2)					
								
		Med Record	2(0.9)					
								
		Missing	2(0.9)					
								
		Parent	221(96.1)					
								
e. Marijuana (primary or second hand smoke)	EXPOS_MARIJU	No	225(97.8)					
								
		Yes	5(2.2)					
								
Source code	EXP_MARIJ_SC	Both	5(2.2)					
								
		Med Record	3(1.3)					
								
		Missing	1(0.4)					
								
		Parent	221(96.1)					
								
f. General anesthesia	EXPOS_ANESTH	Missing	1(0.4)					
								
		No	225(97.8)					
								
		Yes	4(1.7)					
								
Source code	EXP_ANEST_SC	Both	5(2.2)					
								
		Med Record	1(0.4)					
								
		Missing	2(0.9)					
								
		Parent	222(96.5)					
								
g. Prescription medications	EXPOS_PRESCR	Don't know	1(0.4)					
								
		Missing	1(0.4)					
								
		No	138(60.0)					
								
		Yes	90(39.1)					
								
Source code	EXP_PRESC_SC	Both	4(1.7)					
								
		Med Record	2(0.9)					
								
		Missing	2(0.9)					
								
		Parent	222(96.5)					
								
i. IF YES: How many medications	PREG_MEDS			88(142)	1.63(1.00)	1.00(1.00,2.00)	1.00-5.00	
								
B7gii1. Medication name	MEDS_NAME1			()	()	(,)	-	
								
B7gii2. Medication name	MEDS_NAME2			()	()	(,)	-	
								
B7gii3. Medication name	MEDS_NAME3			()	()	(,)	-	
								
B7gii4. Medication name	MEDS_NAME4			()	()	(,)	-	
								
B7gii5. Medication name	MEDS_NAME5			()	()	(,)	-	
								
B7gii1i1. Medication code	MED_CODE1			()	()	(,)	-	
								
B7gii1i2. Medication code	MED_CODE2			()	()	(,)	-	
								
B7gii1i3. Medication code	MED_CODE3			()	()	(,)	-	
								
B7gii1i4. Medication code	MED_CODE4			()	()	(,)	-	
								
B7gii1i5. Medication code	MED_CODE5			()	()	(,)	-	
								
a. Too much amniotic fluid.	AMN_FLUID_P	Don't know	3(1.3)					
								
		Missing	1(0.4)					
								
		No	218(94.8)					
								
		Yes	8(3.5)					
								
Source code	FLUID_P_SC	Both	6(2.6)					
								
		Med Record	2(0.9)					
								
		Missing	2(0.9)					
								
		Parent	220(95.7)					
								
b. Not enough amniotic fluid.	AMN_FLUID_O	Don't know	3(1.3)					
								
		Missing	9(3.9)					
								
		No	200(87.0)					
								
		Yes	18(7.8)					
								
Source code	FLUID_O_SC	Both	5(2.2)					
								
		Med Record	2(0.9)					
								
		Missing	10(4.3)					
								
		Parent	213(92.6)					
								
c. High blood pressure (diagnosed during pregnancy)	HBP	Missing	1(0.4)					
								
		No	212(92.2)					
								
		Yes	17(7.4)					
								
Source code	HBP_SC	Both	6(2.6)					
								
		Med Record	1(0.4)					
								
		Missing	2(0.9)					
								
		Parent	221(96.1)					
								
d. Diabetes (present before pregnancy)	DIABETES_M	Missing	1(0.4)					
								
		No	221(96.1)					
								
		Yes	8(3.5)					
								
Source code	DIAB_M_SC	Both	6(2.6)					
								
		Med Record	1(0.4)					
								
		Missing	2(0.9)					
								
		Parent	221(96.1)					
								
e. New diagnosis of diabetes (GESTATIONAL DIABETES)	DIABETES_G	Missing	9(3.9)					
								
		No	209(90.9)					
								
		Yes	12(5.2)					
								
Source code	DIAB_G_SC	Both	6(2.6)					
								
		Med Record	1(0.4)					
								
		Missing	10(4.3)					
								
		Parent	213(92.6)					
								
f. German measles (Rubella)	RUBELLA	Missing	1(0.4)					
								
		No	229(99.6)					
								
Source code	RUBELLA_SC	Both	6(2.6)					
								
		Med Record	1(0.4)					
								
		Missing	2(0.9)					
								
		Parent	221(96.1)					
								
fi. IF YES: In which trimester of your (the mother's) pregnancy did you(she) first have German measles (rubella)?	RUBELLA_TRIM	Skipped	230(100.0)					
								
a. Fever > 102F	FEVER	Don't know	6(2.6)					
								
		Missing	1(0.4)					
								
		No	211(91.7)					
								
		Yes	12(5.2)					
								
Source code	FEVER_SC	Both	6(2.6)					
								
		Med Record	1(0.4)					
								
		Missing	2(0.9)					
								
		Parent	221(96.1)					
								
i. First trimester	FEVER_1	No	6(2.6)					
								
		Skipped	218(94.8)					
								
		Yes	6(2.6)					
								
Source code	FEVER_1_SC	Med Record	1(0.4)					
								
		Parent	11(4.8)					
								
		Skipped	218(94.8)					
								
ii. Second trimester	FEVER_2	No	8(3.5)					
								
		Skipped	218(94.8)					
								
		Yes	4(1.7)					
								
Source code	FEVER_2_SC	Med Record	1(0.4)					
								
		Parent	11(4.8)					
								
		Skipped	218(94.8)					
								
iii. Third trimester	FEVER_3	No	8(3.5)					
								
		Skipped	218(94.8)					
								
		Yes	4(1.7)					
								
Source code	FEVER_3_SC	Med Record	1(0.4)					
								
		Parent	11(4.8)					
								
		Skipped	218(94.8)					
								
b. Bladder infection (or UTI)	UTI	Don't know	3(1.3)					
								
		Missing	1(0.4)					
								
		No	198(86.1)					
								
		Yes	28(12.2)					
								
Source code	UTI_SC	Both	7(3.0)					
								
		Med Record	1(0.4)					
								
		Missing	2(0.9)					
								
		Parent	220(95.7)					
								
i. First trimester	UTI_1	Don't know	3(1.3)					
								
		No	9(3.9)					
								
		Skipped	202(87.8)					
								
		Yes	16(7.0)					
								
Source code	UTI_1_SC	Both	1(0.4)					
								
		Med Record	1(0.4)					
								
		Parent	26(11.3)					
								
		Skipped	202(87.8)					
								
ii. Second trimester	UTI_2	Don't know	3(1.3)					
								
		No	18(7.8)					
								
		Skipped	202(87.8)					
								
		Yes	7(3.0)					
								
Source code	UTI_2_SC	Both	1(0.4)					
								
		Med Record	1(0.4)					
								
		Parent	26(11.3)					
								
		Skipped	202(87.8)					
								
iii. Third trimester	UTI_3	Don't know	3(1.3)					
								
		No	15(6.5)					
								
		Skipped	202(87.8)					
								
		Yes	10(4.3)					
								
Source code	UTI_3_SC	Both	1(0.4)					
								
		Med Record	1(0.4)					
								
		Parent	26(11.3)					
								
		Skipped	202(87.8)					
								
B10. Did you (the mother) have any other infections during your (her) pregnancy?	INFECTION	Don't know	2(0.9)					
								
		Missing	1(0.4)					
								
		No	182(79.1)					
								
		Yes	45(19.6)					
								
Source code	INFECTION_SC	Both	7(3.0)					
								
		Med Record	1(0.4)					
								
		Missing	2(0.9)					
								
		Parent	220(95.7)					
								
a. How many other infections did you (the mother) have during your (her) pregnancy?	INFECT_NUM			44(186)	1.11(0.32)	1.00(1.00,1.00)	1.00-2.00	
								
B10b1. Name of infection	INFECT_NAME1			()	()	(,)	-	
								
B10b2. Name of infection	INFECT_NAME2			()	()	(,)	-	
								
B10bi1. Infection in the 1st trimester	INFECT_TRIM1_1	Don't know	2(0.9)					
								
		Missing	2(0.9)					
								
		No	22(9.6)					
								
		Skipped	185(80.4)					
								
		Yes	19(8.3)					
								
B10bi2. Infection in the 1st trimester	INFECT_TRIM1_2	Don't know	1(0.4)					
								
		Missing	40(17.4)					
								
		No	2(0.9)					
								
		Skipped	185(80.4)					
								
		Yes	2(0.9)					
								
B10bi1. Infection source code	INFECT_T1_SC1	Both	1(0.4)					
								
		Med Record	1(0.4)					
								
		Missing	2(0.9)					
								
		Parent	41(17.8)					
								
		Skipped	185(80.4)					
								
B10bi2. Infection source code	INFECT_T1_SC2	Missing	40(17.4)					
								
		Parent	5(2.2)					
								
		Skipped	185(80.4)					
								
B10bii1. Infection in the 2nd trimester	INFECT_TRIM2_1	Don't know	3(1.3)					
								
		Missing	2(0.9)					
								
		No	28(12.2)					
								
		Skipped	185(80.4)					
								
		Yes	12(5.2)					
								
B10bii2. Infection in the 2nd trimester	INFECT_TRIM2_2	Don't know	1(0.4)					
								
		Missing	40(17.4)					
								
		No	3(1.3)					
								
		Skipped	185(80.4)					
								
		Yes	1(0.4)					
								
B10bii1. Infection source code	INFECT_T2_SC1	Both	1(0.4)					
								
		Med Record	1(0.4)					
								
		Missing	2(0.9)					
								
		Parent	41(17.8)					
								
		Skipped	185(80.4)					
								
B10bii2. Infection source code	INFECT_T2_SC2	Missing	40(17.4)					
								
		Parent	5(2.2)					
								
		Skipped	185(80.4)					
								
B10biii1. Infection in the 3rd trimester	INFECT_TRIM3_1	Don't know	3(1.3)					
								
		Missing	2(0.9)					
								
		No	25(10.9)					
								
		Skipped	185(80.4)					
								
		Yes	15(6.5)					
								
B10biii2. Infection in the 3rd trimester	INFECT_TRIM3_2	Don't know	1(0.4)					
								
		Missing	40(17.4)					
								
		No	3(1.3)					
								
		Skipped	185(80.4)					
								
		Yes	1(0.4)					
								
B10biii1. Infection source code	INFECT_T3_SC1	Both	1(0.4)					
								
		Med Record	1(0.4)					
								
		Missing	2(0.9)					
								
		Parent	41(17.8)					
								
		Skipped	185(80.4)					
								
B10biii2. Infection source code	INFECT_T3_SC2	Missing	40(17.4)					
								
		Parent	5(2.2)					
								
		Skipped	185(80.4)					
								
B11. Did you (the mother) have any other complications during your(her) pregnancy?	COMPLICATION	Missing	1(0.4)					
								
		No	189(82.2)					
								
		Yes	40(17.4)					
								
Source code	COMPLIC_SC	Both	6(2.6)					
								
		Med Record	1(0.4)					
								
		Missing	2(0.9)					
								
		Parent	221(96.1)					
								
a. How many other complications did you(the mother) have during your(her) pregnancy?	COMP_NUM			40(190)	1.30(0.56)	1.00(1.00,1.50)	1.00-3.00	
								
B11b1. Type of complication	COMPL_NAME1			()	()	(,)	-	
								
B11b2. Type of complication	COMPL_NAME2			()	()	(,)	-	
								
B11b3. Type of complication	COMPL_NAME3			()	()	(,)	-	
								
B11bi1. Complication in first trimester	COMPL_TRIM1_1	No	23(10.0)					
								
		Skipped	190(82.6)					
								
		Yes	17(7.4)					
								
B11bi2. Complication in first trimester	COMPL_TRIM1_2	Missing	30(13.0)					
								
		No	9(3.9)					
								
		Skipped	190(82.6)					
								
		Yes	1(0.4)					
								
B11bi3. Complication in first trimester	COMPL_TRIM1_3	Missing	38(16.5)					
								
		No	1(0.4)					
								
		Skipped	190(82.6)					
								
		Yes	1(0.4)					
								
B11bi1. Complication source code	COMPL_T1_SC1	Parent	40(17.4)					
								
		Skipped	190(82.6)					
								
B11bi2. Complication source code	COMPL_T1_SC2	Missing	30(13.0)					
								
		Parent	10(4.3)					
								
		Skipped	190(82.6)					
								
B11bi3. Complication source code	COMPL_T1_SC3	Missing	38(16.5)					
								
		Parent	2(0.9)					
								
		Skipped	190(82.6)					
								
B11bii1. Complication in 2nd trimester	COMPL_TRIM2_1	No	23(10.0)					
								
		Skipped	190(82.6)					
								
		Yes	17(7.4)					
								
B11bii2. Complication in 2nd trimester	COMPL_TRIM2_2	Missing	30(13.0)					
								
		No	6(2.6)					
								
		Skipped	190(82.6)					
								
		Yes	4(1.7)					
								
B11bii3. Complication in 2nd trimester	COMPL_TRIM2_3	Missing	38(16.5)					
								
		Skipped	190(82.6)					
								
		Yes	2(0.9)					
								
B11bii1. Complication source code	COMPL_T2_SC1	Parent	40(17.4)					
								
		Skipped	190(82.6)					
								
B11bii2. Complication source code	COMPL_T2_SC2	Missing	30(13.0)					
								
		Parent	10(4.3)					
								
		Skipped	190(82.6)					
								
B11bii3. Complication source code	COMPL_T2_SC3	Missing	38(16.5)					
								
		Parent	2(0.9)					
								
		Skipped	190(82.6)					
								
B11cii1. Complication in 3rd trimester	COMPL_TRIM3_1	No	21(9.1)					
								
		Skipped	190(82.6)					
								
		Yes	19(8.3)					
								
B11cii2. Complication in 3rd trimester	COMPL_TRIM3_2	Missing	30(13.0)					
								
		No	4(1.7)					
								
		Skipped	190(82.6)					
								
		Yes	6(2.6)					
								
B11cii3. Complication in 3rd trimester	COMPL_TRIM3_3	Missing	38(16.5)					
								
		Skipped	190(82.6)					
								
		Yes	2(0.9)					
								
B11cii1. Complication source code	COMPL_T3_SC1	Parent	40(17.4)					
								
		Skipped	190(82.6)					
								
B11cii2. Complication source code	COMPL_T3_SC2	Missing	30(13.0)					
								
		Parent	10(4.3)					
								
		Skipped	190(82.6)					
								
B11cii3. Complication source code	COMPL_T3_SC3	Missing	38(16.5)					
								
		Parent	2(0.9)					
								
		Skipped	190(82.6)					
								
C1. How many pregnancies have you (has the mother) had as of today's date,including the child in this study?	PREG_NUM	four to five	48(20.9)					
								
		one	31(13.5)					
								
		six to twelve	25(10.9)					
								
		three	65(28.3)					
								
		two	61(26.5)					
								
C2. How many living siblings does the child in this study have in total, including both full and half siblings?	SIB_ALIVE	one	85(37.0)					
								
		three to eleven	40(17.4)					
								
		two	68(29.6)					
								
		zero	37(16.1)					
								
C3. Have you (Has the mother) had any miscarriages?	MISCARR	Missing	1(0.4)					
								
		No	141(61.3)					
								
		Yes	88(38.3)					
								
Source code	MISCARR_SC	Both	4(1.7)					
								
		Med Record	1(0.4)					
								
		Missing	2(0.9)					
								
		Parent	223(97.0)					
								
a. IF YES: How many miscarriages have you (has the mother) had?	MISCARR_NUM			88(142)	1.49(1.08)	1.00(1.00,1.50)	1.00-7.00	
								
C4. Have you (has the mother) ended or terminated any pregnancies?	PREG_TERMIN	Missing	1(0.4)					
								
		No	202(87.8)					
								
		Yes	27(11.7)					
								
Source code	PREG_TERM_SC	Both	4(1.7)					
								
		Med Record	1(0.4)					
								
		Missing	2(0.9)					
								
		Parent	223(97.0)					
								
a. IF YES: How many pregnancies were ended or terminated?	PREG_TERM_NU			27(203)	1.22(0.70)	1.00(1.00,1.00)	1.00-4.00	
								
Sum of miscarriages and terminated pregnancies	SUM_TERM			101(129)	1.62(1.14)	1.00(1.00,2.00)	1.00-7.00	
								
C5. Did you (did the mother) ever terminate a pregnancy due to a known cardiac defect?	PREG_CARD	Missing	203(88.3)					
								
		No	26(11.3)					
								
		Yes	1(0.4)					
								
Source code	PREG_CARD_SC	Both	1(0.4)					
								
		Missing	203(88.3)					
								
		Parent	26(11.3)					
								
a. Specify	PREG_CARD_SP			()	()	(,)	-	
								
C6. Have any of the study subject's siblings passed away,including both full and half siblings?	SIBLING_DEAD	No	225(97.8)					
								
		Yes	5(2.2)					
								
Source code	SIBLING_D_SC	Both	5(2.2)					
								
		Med Record	1(0.4)					
								
		Missing	2(0.9)					
								
		Parent	222(96.5)					
								
a. IF YES: How many?	SIB_DEAD			5(225)	1.00(0.00)	1.00(1.00,1.00)	1.00-1.00	
								
Z1. How long did it take to complete this form?	COMP_TIME			229(1)	20.69(16.56)	15.00(10.00,25.00)	2.00-120.00