Marfan Syndrome (MFS) is a disorder that can affect the heart and large blood vessels as well as eyes, muscles, bones and lungs. The most serious problems can happen when the body’s largest blood vessel, the aorta, becomes enlarged in individuals with MFS.
This study was done to compare two drugs (Atenolol and Losartan) to see if one is better than the other at slowing the speed of aortic enlargement. The study also compared the kinds of side effects that can occur when taking either of these medicines. The study enrolled 608 individuals, ages 6 months to 25 years.
This study enrolled 608 participants.
Participants ages ranged from 6 months to 25 years of age.
We found both medications worked equally to control the rate of aortic-root dilatation over a 3-year period.
Among children and young adults with Marfan’s syndrome who were randomly assigned to losartan or atenolol, we found no significant difference in the rate of aortic-root dilatation between the two treatment groups over a 3-year period. Both drugs were tolerated well and no differences were seen in side effects between the two groups.
R. Lacro, N Engl J Med 2014; 371:2061-2071.
Among 608 children and young adults with Marfan’s syndrome (ages 6 months to 26 years) who were randomly assigned to losartan or atenolol, we found no significant difference in the rate of aortic-root dilatation between the two treatment groups over a 3-year period. Aortic-root surgery, aortic dissection, death, and a composite of these events did not differ significantly between the two treatment groups.
R. Lacro, Am Heart J 2007; 154:624-631.
The leading cause of death in people with Marfan syndrome is dilation, tearing and rupture of the aorta, the large artery that delivers blood from the heart to the body. Recent studies in mice with Marfan syndrome showed that treatment with Losartan, a medication used to treat high blood pressure, prevented dilation and improved the structure of the wall of the aorta. This article describes the design of a trial to compare Losartan to the standard medication (Atenolol) for patients with Marfan syndrome. The goal of the trial is to follow over 600 children and young adults for 3 years to determine which drug does a better job slowing the rate of growth of the aorta.
E. Selamet Tierney, J Am Soc Echocardiogr 2013; 26(6):657-666.
This study describes the characteristics of the echocardiograms for subjects enrolled in the clinical trial. Even when different doctors reviewed and measured the aortas and heart structures of the trial participants, there was excellent agreement in the measurements. Having good agreement is important for accurately reporting the results of the clinical trial.
R. Lacro, Am Heart J 2013; 165:828-835.e3.
This paper describes the population that was screened and then enrolled in the clinical trial. The average age at study entry was 11.2 years, 60% were male, and 25% were older teenagers and young adults. Aortic root diameter z-score was 4.0 and wasn’t different by age. Mitral valve prolapse and mitral regurgitation were more common in females. 56% had a family member with aortic surgery and 32% had a family member with a history of aortic dissection.
ES. Selamet Tierney, Am J Cardiol 2018 May 1;121(9):1094-1101.
The PHN randomized trial of atenolol versus losartan in Marfan Syndrome showed no treatment differences in the rates of aortic-root growth or clinical outcomes. This analysis examined treatment effects on aortic stiffness and determined whether baseline aortic stiffness predicts aortic-root growth and clinical outcomes. There was no treatment effect on the rate of change for ascending-aorta stiffness index, aortic-root elastic modulus, or ascending-aorta elastic modulus. We found that atenolol therapy was associated with a fall in aortic-root stiffness index, while losartan therapy was not. Higher baseline aortic-root stiffness index and elastic modulus were associated with a smaller decrease in aortic root z-score and increased risk for clinical outcomes. These data suggest that non-invasive aortic stiffness measures may identify patients at higher risk for progressive aortic enlargement and adverse clinical outcomes, potentially allowing for closer monitoring and more aggressive therapy for such patients.
A. Hoskoppal, Pediatr Cardiol 2018 Jun 11. doi: 10.1007/s00246-018-1916-6.
This was a secondary analysis of the PHN randomized clinical trial of atenolol vs. losartan in patients with Marfan syndrome that attempted to identify factors that predict rapid aortic root dilation and referral for aortic surgery. We found some statistically significant but only weakly predictive associations between more rapid aortic root dilation and older age, non-white race, and one aortic measurement: higher sinotubular junction z-score. We found similarly statistically significant but only weakly predictive associations between referral for aortic root surgery and some aortic measurements (larger aortic root diameter, higher ascending aorta z-score, and higher ratio between the diameters of the sinotubular junction and ascending aorta). Future studies may clarify whether monitoring generalized proximal aortic dilation and effacement of the sinotubular junction will help to risk-stratify young patients with Marfan syndrome and inform medical and surgical management.
D. Y. Mah, Am J Cardiol. 2018 Jul 17. pii: S0002-9149(18)31424-3. doi: 10.1016/j.amjcard.2018.07.006.
J. C. Handisides, J Pediatr. 2019 Jan;204:250-255.e1. doi: 10.1016/j.jpeds.2018.08.061.
S. Driest, J Pediatr. 2020 Jul;222:213-220.e5. doi: 10.1016/j.jpeds.2020.03.064.
M. S. Hamstra, Clin Trials 2020 Aug 21;1740774520945988. doi: 10.1177/1740774520945988.